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Table 4 Interaction and stratified analysis results for the association between marijuana use and GAA at examination years 15 and 20 by strata of alcohol consumption

From: Marijuana use and DNA methylation-based biological age in young adults

 

Year 15

Year 20

GEE

Î’marijuana [95% CI]

P

Î’marijuana [95% CI]

P

Î’marijuana [95% CI]

P

Ever marijuana use

− 0.01 [− 0.04, 0.02]

0.678

− 0.04 [− 0.07, 0.00]

0.040*

− 0.02 [− 0.06, 0.02]

0.386

 Nondrinker

0.96 [0.26, 1.66]

0.007

0.18 [− 0.59, 0.94]

0.645

0.58 [0.03, 1.13]

0.040

 Light drinker

0.58 [− 0.61, 1.76]

0.338

0.15 [− 1.05, 1.35]

0.805

0.39 [− 0.29, 1.08]

0.260

 Moderate drinker

0.30 [− 0.91, 1.51]

0.627

0.34 [− 0.93, 1.61]

0.596

0.37 [− 0.58, 1.31]

0.449

 Heavy drinker

0.03 [− 2.06, 2.11]

0.981

− 1.69 [− 4.02, 0.64]

0.154

− 0.52 [− 2.53, 1.48]

0.609

Cumulative marijuana use

− 0.01 [− 0.01, 0.00]

0.017*

0.00 [− 0.01, 0.00]

0.007*

− 0.01 [− 0.01, 0.00]

0.011*

 Nondrinker

0.22 [0.02, 0.42]

0.035

0.22 [0.06, 0.37]

0.006

0.21 [0.05, 0.36]

0.008

 Light drinker

0.58 [0.34, 0.81]

< 0.001

0.22 [− 0.13, 0.56]

0.221

0.48 [0.24, 0.72]

< 0.001

 Moderate drinker

0.16 [− 0.04, 0.37]

0.115

0.35 [0.17, 0.53]

< 0.001

0.30 [0.15, 0.45]

< 0.001

 Heavy drinker

0.10 [− 0.12, 0.31]

0.388

0.02 [− 0.14, 0.18]

0.776

0.05 [− 0.09, 0.18]

0.500

Recent marijuana use

− 0.02 [− 0.04, 0.00]

0.034*

− 0.03 [− 0.05, − 0.02]

0.001*

− 0.03 [− 0.04, − 0.01]

0.002*

 Nondrinker

1.56 [0.16, 2.97]

0.029

1.30 [− 0.02, 2.61]

0.053

1.44 [0.09, 2.78]

0.036

 Light drinker

3.51 [1.96, 5.05]

< 0.001

1.34 [− 0.87, 3.55]

0.233

2.93 [1.31, 4.54]

< 0.001

 Moderate drinker

1.07 [− 0.12, 2.27]

0.079

1.93 [0.66, 3.19]

0.003

1.72 [0.72, 2.71]

< 0.001

 Heavy drinker

0.55 [− 0.89, 1.98]

0.451

0.44 [− 1.27, 2.15]

0.610

0.61 [− 0.47, 1.68]

0.270

Recent marijuana use quantity

0.00 [− 0.01, 0.00]

0.026*

0.00 [0.00, 0.00]

0.032*

0.00 [0.00, 0.00]

0.013*

 Nondrinker

0.13 [0.05, 0.22]

0.003

0.12 [0.04, 0.21]

0.006

0.13 [0.05, 0.22]

0.002

 Light drinker

0.23 [0.13, 0.34]

< 0.001

0.06 [− 0.10, 0.22]

0.475

0.18 [0.07, 0.29]

0.001

 Moderate drinker

0.01 [− 0.07, 0.09]

0.748

0.16 [0.06, 0.26]

0.001

0.09 [0.00, 0.17]

0.045

 Heavy drinker

0.04 [− 0.05, 0.12]

0.366

0.02 [− 0.07, 0.11]

0.648

0.03 [− 0.03, 0.10]

0.343

  1. *Interaction terms with P ≤ 0.05
  2. Bolded values represent the beta coefficient [95% CI] and P for the joint association between marijuana use and alcohol consumption
  3. Results are adjusted for sex, race, center, education, tobacco smoking status, cumulative packs of cigarettes, BMI, and physical activity, with cumulative marijuana analyses further adjusted for ever marijuana use
  4. Beta coefficient for ever marijuana use, cumulative marijuana use, recent marijuana use, and recent marijuana use quantity represents gain in GAA for ever users, for each additional marijuana-year, use in the last 30 days, and for each additional day within the last 30 days, respectively
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Clinical Epigenetics

ISSN: 1868-7083

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