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Table 2 Analysis results for the association between cumulative marijuana use and EAA at examination years 15 and 20

From: Marijuana use and DNA methylation-based biological age in young adults

 

Year 15

Year 20

GEE

β [95% CI]

P

β [95% CI]

P

β [95% CI]

P

Ever marijuana use

 IEAA

− 0.07 [− 0.71, 0.57]

0.832

− 0.40 [− 1.10, 0.30]

0.264

− 0.24 [− 0.78, 0.30]

0.387

 EEAA

0.26 [− 0.50, 1.02]

0.504

0.03 [− 0.76, 0.81]

0.950

0.14 [− 0.45, 0.73]

0.643

 PAA

0.44 [− 0.45, 1.33]

0.336

− 0.39 [− 1.35, 0.58]

0.433

0.07 [− 0.63, 0.76]

0.852

 GAA

0.71 [0.20, 1.23]

0.007

0.22 [− 0.33, 0.76]

0.430

0.49 [0.07, 0.90]

0.022

Cumulative marijuana use

 IEAA

− 0.04 [− 0.17, 0.09]

0.535

− 0.03 [− 0.15, 0.08]

0.558

− 0.04 [− 0.13, 0.05]

0.427

 EEAA

0.04 [− 0.11, 0.20]

0.572

− 0.07 [− 0.20, 0.05]

0.237

− 0.03 [− 0.14, 0.08]

0.556

 PAA

− 0.05 [− 0.24, 0.13]

0.564

− 0.02 [− 0.17, 0.14]

0.837

− 0.04 [− 0.18, 0.10]

0.578

 GAA

0.25 [0.15, 0.36]

< 0.001

0.19 [0.11, 0.28]

< 0.001

0.21 [0.12, 0.30]

< 0.001

  1. Results are adjusted for sex, race, center, education, tobacco smoking status, cumulative packs of cigarettes, BMI, physical activity, and alcohol consumption, with cumulative marijuana analyses further adjusted for ever marijuana use
  2. Beta coefficient for ever marijuana use represents gain in EAA for ever users and beta coefficient for cumulative marijuana use represents gain in EAA for each additional marijuana-year
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Clinical Epigenetics

ISSN: 1868-7083

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