Skip to main content

Table 4 Cross-lagged association between BMI and lipid measures or between BMI and DNA methylation

From: Temporal associations between leukocytes DNA methylation and blood lipids: a longitudinal study

Lipid measures or CpG

Gene

BMIbaseline → Traitfollow-up

Traitbaseline → BMIfollow-up

Model fit

β

SE

P

β

SE

P

SRMR

CFI

BMI and lipid measures

         

TG

–

0.0675

0.0199

0.0007

0.0698

0.1133

0.5376

 < 0.001

1

HDL

–

− 0.0467

0.0113

 < 0.0001

− 0.0009

0.2667

0.9972

 < 0.001

1

BMI and CpG sites

         

cg06500161

ABCG1

0.1853

0.0558

0.0018

− 0.0019

0.0387

0.9600

 < 0.001

1

cg11024682

SREBF1

0.1062

0.0512

0.0380

0.0237

0.0428

0.9600

 < 0.001

1

  1. Adjusted P-values less than 0.05 are in bold font
  2. β, regression coefficient; SE, standard error; TG, triglyceride; HDL-C, high-density lipoprotein-cholesterol; SRMR, standardized root mean squared residual; CFI, comparative fit index