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Table 2 Associations between DNA methylation and lipid measures (Model 1)

From: Temporal associations between leukocytes DNA methylation and blood lipids: a longitudinal study

CpG

Discovery stage

Replication stage

Position

Gene

β

SE

Padj

β

SE

Padj

TG

        

cg06500161

0.0130

0.0013

2.41E−14

0.0088

0.0013

1.51E−10

21:43,656,587

ABCG1

cg00574958

− 0.0074

0.0008

3.63E−12

− 0.0084

0.0010

1.20E−14

11:68,607,622

CPT1A

cg11024682

0.0085

0.0011

1.77E−09

0.0059

0.0011

9.33E−08

17:17,730,094

SREBF1

cg19693031

− 0.0211

0.0027

2.41E−09

− 0.0110

0.0022

1.15E−06

1:145,441,552

TXNIP

cg17058475

− 0.0084

0.0011

4.34E−08

− 0.0100

0.0012

5.70E−16

11:68,607,737

CPT1A

cg07504977

0.0102

0.0014

6.70E−07

0.0066

0.0016

3.47E−05

10:102,131,012

OLMALINC

cg27243685

0.0090

0.0013

3.88E−06

0.0084

0.0014

4.42E−09

21:43,642,366

ABCG1

cg01176028

0.0055

0.0009

5.82E−04

0.0047

0.0010

1.88E−06

21:43,653,234

ABCG1

cg05778424

0.0078

0.0014

7.36E−04

0.0057

0.0012

7.46E−06

17:55,169,508

AKAP1

cg08857797

0.0087

0.0016

3.16E−03

0.0073

0.0016

5.06E−06

17:40,927,699

VPS25

cg26403843

0.0108

0.0020

3.96E−03

0.0062

0.0024

1.11E−02

5:158,634,085

RNF145

cg06690548

− 0.0089

0.0017

1.44E–02

− 0.0037

0.0013

6.10E−03

4:139,162,808

SLC7A11

cg09737197

− 0.0059

0.0012

2.13E−02

− 0.0068

0.0012

7.32E−08

11:68,607,675

CPT1A

cg20544516

0.0054

0.0011

2.40E−02

0.0066

0.0011

7.27E−09

17:17,717,183

MIR33B; SREBF1

cg05176551

0.0079

0.0016

3.24E−02

0.0064

0.0014

5.83E−06

10:32,701,586

CCDC7

TC

        

cg12054453

0.0395

0.0060

5.95E−05

0.0154

0.0059

1.22E−02

17:57,915,717

TMEM49

cg19693031

− 0.0416

0.0078

2.76E−02

− 0.0286

0.0062

1.62E−05

1:145,441,552

TXNIP

cg18942579

0.0278

0.0053

4.23E−02

0.0138

0.0055

1.22E−02

17:57,915,773

TMEM49

HDL-C

        

cg06500161

− 0.0218

0.0031

4.23E−06

− 0.0204

0.0032

9.44E−10

21:43,656,587

ABCG1

cg17901584

0.0243

0.0043

3.01E−03

0.0305

0.0048

9.44E−10

1:55,353,706

DHCR24

cg11024682

− 0.0138

0.0024

3.01E−03

− 0.0122

0.0027

6.44E−06

17:17,730,094

SREBF1

cg27243685

− 0.0167

0.0030

6.39E−03

− 0.0166

0.0034

2.05E−06

21:43,642,366

ABCG1

cg17507897

− 0.0179

0.0033

1.07E−02

− 0.0093

0.0034

5.96E−03

20:17,943,694

SNX5; SNORD17

  1. The novel CpG sites are in bold font. P-values are adjusted for FDR
  2. β, regression coefficient; SE, standard error; TG, triglyceride; TC, total cholesterol; HDL-C, high-density lipoprotein-cholesterol