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Table 5 Association between cg04026387 with OCT/A measurements in univariable and multivariable linear regression models

From: Genome-wide DNA methylation analysis of extreme phenotypes in the identification of novel epigenetic modifications in diabetic retinopathy

OCT/A measurements*

Univariable model 1

Multivariable model 2§

β

95% CI

P value†

β

95% CI

P value†

SCP VD, %

 Superior

1.4

(− 0.1, 2.8)

0.060

1.0

(− 0.5, 2.5)

0.170

 Inferior

− 0.3

(− 2.2, 1.6)

0.769

0.5

(− 1.7, 2.7)

0.650

 Nasal

1.9

(0.5, 3.3)

0.011

2.2

(1.1, 3.3)

0.001

 Temporal

0.6

(− 1.6, 2.8)

0.567

1.0

(− 1.5, 3.6)

0.404

DCP VD, %

 Superior

− 0.8

(− 1.6, − 0.1)

0.049

 − 0.8

(− 1.7, − 0.1)

0.039

 Inferior

− 1.4

(− 2.4, − 0.4)

0.008

 − 1.5

(− 2.8, − 0.2)

0.028

 Nasal

0.2

(− 0.7, 1.1)

0.682

0.5

(− 0.3, 1.4)

0.203

 Temporal

− 0.3

(− 1.7, 1.1)

0.698

 − 0.5

(− 1.9, 0.8)

0.428

RNFL thickness, µm

 Superior

− 0.1

(− 2.5, 2.3)

0.991

 − 0.8

(− 3.2, 1.4)

0.431

 Inferior

− 1.1

(− 2.6, 0.5)

0.172

0.1

(− 1.8, 2.0)

0.919

 Nasal

− 0.6

(− 2.4, 1.2)

0.491

 − 0.2

(− 2.0, 1.6)

0.809

 Temporal

0.9

(− 0.8, 2.7)

0.261

1.0

(− 0.6, 2.6)

0.190

  1. OCT/A =optical coherence tomography/angiography; SCP = superficial capillary plexus; VD = vessel density; DCP = deep capillary plexus; RNFL = retinal nerve fiber layer; CI = confidential interval; T2DM = type 2 diabetes mellitus; HbA1c = glycated hemoglobin
  2. §Adjusted for age, sex, T2DM duration and HbA1c. *Per percent of methylation change. †Bold indicates statistically significant