Genome-wide DNA methylation analysis of extreme phenotypes in the identification of novel epigenetic modifications in diabetic retinopathy

Table 2 Top 10 significant genes harboring differentially methylated CpG positions (DMPs) between NDR group and DR group

DMS	Gene	CHR	FGD	Cgi	β value			P value
DMS	Gene	CHR	FGD	Cgi	NDR group	DR group	Difference	P value
cg05129572	NEDD4	15	Body	Open sea	0.596	0.430	− 0.166	5.41 × 10⁻⁵
cg12507788	MRPL4	19	TSS1500	Shore	0.759	0.627	− 0.133	7.48 × 10^–5
cg07469467	APAF1	12	Body	Open sea	0.381	0.140	− 0.241	1.52 × 10^–4
cg27535148	COL19A1	6	Body	Open sea	0.381	0.265	− 0.116	1.60 × 10^–4
cg06773116	KCNIP4	4	Body	Open sea	0.503	0.631	0.128	2.2 3 × 10^–4
cg13563074	OVCH2	11	TSS1500	Open sea	0.498	0.397	− 0.101	4.22 × 10^–4
cg02294028	MDFIC	7	Body	Shore	0.427	0.308	− 0.119	4.26 × 10^–4
cg24063962	LOC100130274	8	TSS200	Island	0.607	0.721	0.114	5.02 × 10^–4
cg02738594	CAMK1G	1	Body	Open sea	0.456	0.596	0.140	5.86 × 10^–4
cg11686436	FAM83E	19	Body	Shore	0.824	0.713	− 0.112	6.33 × 10^–4

DMP = differentially methylated CpG position; CHR = chromosome; FGD = functional genomic distribution; Cgi = CpG island; NDR = without any diabetic retinopathy; DR = diabetic retinopathy

ISSN: 1868-7083