Table 2 Sensitivity and specificity of the WID™-qCIN test
Diagnostic validation | Predictive validation | |
|---|---|---|
LBC-CIN Diagnostic | LBC-CIN Predictive | |
All, % (95% CI) | ||
Specificity (≤ CIN1) | 90 (87–93) | 93 (87–97) |
Sensitivity (CIN2) | 55 (42–67) | – |
Sensitivity (CIN3) | 69 (56–80) | 35 (27–44) |
Sensitivity (CIN3+) | 78 (67–86) | 35 (27–44) |
Sensitivity (CC) | 100 (85–100) | – |
PPV (CIN3+) | 59 (52–68) | 57 (43–72) |
NPV (≤ CIN1) | 93 (91–95) | 84 (82–86) |
NPV (≤ CIN2) | 92 (90–95) | 84 (82–86) |
Age < 30 years, % (95% CI) | ||
Specificity (≤ CIN1) | 95 (89–98) | 92 (82–97) |
Sensitivity (CIN2) | 46 (28–66) | – |
Sensitivity (CIN3) | 59 (36–79) | 15 (7–27) |
Sensitivity (CIN3+) | 65 (44–83) | 15 (7–27) |
Sensitivity (CC) | 100 (40–100) | – |
PPV (CIN3+) | 76 (55–91) | 33 (17–58) |
NPV (≤ CIN1) | 91 (86–94) | 80 (78–82) |
NPV (≤ CIN2) | 89 (84–94) | 80 (78–82) |
Age ≥ 30 years, % (95% CI) | ||
Specificity (≤ CIN1) | 88 (83–92) | 94 (85–98) |
Sensitivity (CIN2) | 61 (43–76) | – |
Sensitivity (CIN3) | 75 (59–87) | 52 (40–64) |
Sensitivity (CIN3+) | 83 (71–92) | 52 (40–64) |
Sensitivity (CC) | 100 (82–100) | – |
PPV (CIN3+) | 57 (49–65) | 70 (50–86) |
NPV (≤ CIN1) | 95 (92–97) | 88 (85–90) |
NPV (≤ CIN2) | 94 (91–97) | 88 (85–90) |