Table 1 Overview of datasets
Characteristic | Diagnostic validation | Predictive validation | ||
|---|---|---|---|---|
LBC-CIN Diagnostic | LBC-CIN Predictive | |||
Control n = 355 | Case n = 151 | Control n = 124 | Case n = 131 | |
Age | 33 (27–39) | 33 (27–40) | 31 (26–38) | 30 (26–37) |
Setting, n (%) | Case/control | Cohort (nested case/control) | ||
HPV status | ||||
HPV16/18+ | 56 (16) | 72 (48) | 30 (24) | 73 (56) |
other oncHPV+ | 116 (33) | 58 (38) | 94 (76) | 58 (44) |
oncHPV− | 154 (43) | 1 (0.7) | ||
Unknown | 29 (8.2) | 20 (13) | ||
Diagnosis | ||||
Normal cytology | 239 (67) | 124 (100) | ||
CIN1 | 116 (33) | |||
CIN2 | 66 (44) | |||
CIN3 | 62 (41) | 131 (100) | ||
Invasive cervical cancer | 23 (15) | |||
Time to event (years) | 3.14 (3.03–3.30) | 3.11 (2.66–3.25) | ||