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Fig. 3 | Clinical Epigenetics

Fig. 3

From: DNA methylation-based detection and prediction of cervical intraepithelial neoplasia grade 3 and invasive cervical cancer with the WID™-qCIN test

Fig. 3

Influence of time to future CIN3 on WID™-qCIN in individuals below and above 30 years of age and in relation to HPV status in the LBC-CIN Predictive set. A Scatter plot of time to event (censoring/future cytology negative (cyt−) or CIN3+ diagnosis) versus logarithm of the raw PMR values of the WID™-qCIN. PMR values are visualised on log scale only for illustrative purposes. The dashed line indicates the threshold [log(0.63) = − 0.46]. B AUC of the WID™-qCIN stratified by HPV16/18+ or other oncHPV+ status. Curves are not significantly different (DeLong p value = 0.52). C WID™-qCIN values in HPV16/HPV18+ or other oncHPV+ individuals and future CIN3 cases. CIN3 cervical intraepithelial neoplasia grade 3, cyt− cytology negative, AUC area under the curve, PMR percentage methylated reference, oncHPV oncogenic human papillomavirus

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