Fig. 3

Characterization of the chromosomal deletion from DNA methylation data. A All CpG sites on the chromosome 5p-arm for two representative patients with either short (patient 7) or long (patient 4) deletions. The y-axis shows the patient sum of methylated and unmethylated signal divided by the mean control methylated and unmethylated sum. B Loess smoothing applied to the signal shown in (A), defining the estimated deletion point with a dotted vertical line. Gene positions and cytogenic bands are also shown for the indicated part of chromosome 5