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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Cri du chat syndrome patients have DNA methylation changes in genes linked to symptoms of the disease

Fig. 1

DNA methylation changes and functional enrichment in Cri du chat patients. A Moderated T-statistic for each CpG site calculated from the paired patient/controls and mapped to genomic positions. Here shown for chromosomes 4–6. All chromosomes are shown in Additional file 1: Figure S1. B, C Integration of patient CpG changes on the p-arm of chromosome 5 relative to controls for gene bodies (B) or promoter sequences (C). The y-axis shows the −log10(p.adjusted) of the statistical test measuring the likelihood of patient DNA methylation of that given promoter (or gene body) is be differentially methylated. It is multiplied by the sign of the NES value, meaning strongly positive y-axis values would be significantly increased methylation. The dotted red lines are at y = −2 and 2, representing p.adj < 0.01. All gene bodies or promoters with p.adj < 0.01 are in red with increasing font size for lower p values. D Enrichment analysis with several different types of CpG categorization for the CpGs with p < 0.01 and separated CpGs with less or more methylation in patients

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