Table 2 Top 15 genes associated with the most differentially methylated CpG sites for each endocrine hypertension type
From: Whole blood methylome-derived features to discriminate endocrine hypertension
CS vs. PHT | PPGL vs. PHT | PA vs. PHT | EHT vs. PHT | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | − log10 p value | logFC | Gene | − log10 p value | logFC | Gene | − log10 p value | logFC | Gene | − log10 p value | logFC |
FKBP5 | 15.05 | − 0.40 | MUTYH | 9.46 | − 0.19 | CD300LG | 14.10 | − 0.29 | CD300LG | 12.90 | − 0.27 |
CD68 | 11.21 | − 0.34 | ELAVL1 | 9.43 | − 0.28 | KRAS | 11.41 | − 0.31 | ZNF283 | 10.18 | − 0.25 |
TMEM105 | 11.19 | − 0.14 | NLRC3 | 9.10 | − 0.26 | ZNF689 | 9.85 | − 0.22 | PTPN6 | 9.47 | − 0.23 |
MPO | 11.11 | − 0.31 | RASGEF1C | 9.05 | − 0.15 | C16orf65 | 9.63 | − 0.25 | CCDC33 | 9.43 | − 0.20 |
PDE6A | 10.91 | − 0.31 | STAT6 | 8.89 | − 0.26 | C22orf32 | 9.42 | − 0.36 | STAT6 | 9.20 | − 0.24 |
KDM4A | 10.67 | 0.08 | CD300LG | 8.86 | − 0.24 | MFNG | 9.33 | − 0.26 | MUTYH | 9.20 | − 0.19 |
PCDH24 | 10.63 | − 0.05 | CD44 | 8.69 | − 0.23 | GRB10 | 9.21 | 0.10 | PTPRE | 9.17 | − 0.24 |
SLC1A5 | 10.60 | − 0.41 | MFNG | 8.68 | − 0.28 | PLEKHA2 | 9.18 | − 0.24 | TCN2 | 9.13 | − 0.13 |
GRK6 | 10.57 | − 0.16 | SLC35B1 | 8.60 | − 0.24 | SLC1A5 | 9.02 | − 0.34 | ARHGAP8 | 9.13 | − 0.20 |
NAA50 | 10.43 | − 0.32 | PTPN6 | 8.58 | − 0.25 | GRHPR | 8.98 | − 0.27 | GHDC | 9.09 | − 0.11 |
TTC22 | 10.40 | 0.10 | C16orf65 | 8.51 | − 0.26 | CCRL2 | 8.96 | − 0.27 | SLC2A1 | 9.09 | − 0.24 |
DIP2A | 10.28 | 0.20 | PADI4 | 8.31 | − 0.26 | FOXO1 | 8.91 | − 0.36 | SH2D3C | 9.07 | − 0.25 |
ADGRE5 | 10.25 | − 0.31 | FGD3 | 8.24 | − 0.25 | CACNA1G | 8.90 | − 0.41 | NLRC3 | 9.00 | − 0.23 |
MIR6840 | 10.25 | 0.19 | TLCD1 | 8.21 | 0.30 | CHD9 | 8.90 | − 0.22 | ELAVL1 | 8.99 | − 0.13 |
TCEA2 | 10.13 | 0.01 | DMKN | 8.09 | − 0.26 | TIPARP− AS1 | 8.87 | − 0.40 | CD93 | 8.95 | − 0.21 |