Fetal exposure to phthalates and bisphenols and DNA methylation at birth: the Generation R Study

Clinical Epigenetics

Table 3 CpGs with p values < 1.0 * 10^–6 from epigenome-wide association study of a mixture of phthalates and bisphenols in maternal urine during first, second and third trimester and DNA methylation in cord blood

	CpG	Chr	Position	Gene	Effect	SE	p value
First trimester	cg05058973	7	31002599	GHRHR	− 1.20 * 10^–2	2.37 * 10^–3	7.08 * 10^–7
Second trimester	cg00141688	2	10517352	HPCAL1	1.59 * 10^–2	2.93 * 10^–3	1.21 * 10^–7
	cg15961211	1	43613440	FAM183A	3.65 * 10^–3	7.11 * 10^–4	5.32 * 10^–7
	cg20840540	6	42363749	TRERF1	− 1.28 * 10^–2	2.52 * 10^–3	7.54 * 10^–7

There were no CpGs presented for third trimester, as none reached our uncorrected p value cutoff of < 1.0 * 10^–6. There were no associations that reached significance (p value < 0.05) after further FDR-adjustment of the p value for multiple testing including the three trimesters
^#We have indicated probes that map to DNA containing a single nucleotide polymorphism (SNP), repetitive sequence elements or DNA harboring an insertion or deletion with a ‘1’ in this column

ISSN: 1868-7083