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Fig. 4 | Clinical Epigenetics

Fig. 4

From: 5-Hydroxymethylation alterations in cell-free DNA reflect molecular distinctions of diffuse large B cell lymphoma at different primary sites

Fig. 4

A The 40,207 primary sites differential 5hmC regions (psDhMRs) among patients with DLBCL at different primary sites and healthy controls. B t-SNE plot of 40,207 psDhMRs in cfDNA among patients with DLBCL at different primary sites and healthy controls. C The 38,219 psDhMRs between the IP-DLBCL group and the non-IP-DLBCL group. D The pie chart shows 5hmC-gain and 5hmC-loss psDhMRs in the IP-DLBCL group compared with the non-IP-DLBCL group. E t-SNE plot of 38,219 psDhMRs in cfDNA between IP-DLBCL and non-IP-DLBCL. F The top enriched known transcription factor binding motifs detected in psDhMRs in the IP-DLBCL and non-IP-DLBCL groups. Motif information was obtained from the Homer motif database. The value in parenthesis represents the percentage of target sequences enriched with the binding motif of the indicated transcription factor

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Clinical Epigenetics

ISSN: 1868-7083

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