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Table 1 Clinical characteristics of the individuals from FHS

From: Identification of DNA methylation-regulated genes as potential biomarkers for coronary heart disease via machine learning in the Framingham Heart Study

Characteristic

Training controls

Training CHD patients

p value

Validation controls

Validation CHD patients

p value

Number

1364

199

–

455

67

–

Male/Female

554/810

95/104

0.0644c

186/269

32/35

0.2917c

Age (year)

66 (60, 72)

66 (61, 72)

0.1747b

60 (52, 65)

63 (53, 67)

0.2557 b

Smoker / non-smoker

101 / 1261

19 / 180

0.3173c

39 / 416

10 / 57

0.1138c

BMI (kg/m2)

27.55 (24.51, 30.84)

29.38 (25.30, 32.70)

0.0003b

27.39 (24.82, 30.90)

28.97 (26.48, 33.15)

0.0133b

FBG (mg/dL)

101.00 (95.00, 110.00)

106.00 (97.00, 120.00)

 < 0.0001b

101.00 (94.00, 110.30)

109.00 (99.00, 122.00)

0.0005b

SBP (mmHg)

127.00 (117.00, 139.00)

130.50 (118.00, 141.30)

0.1229b

127.00 (116.00, 139.00)

128.50 (118.00, 139.00)

0.4886b

DBP (mmHg)

74.00 (68.00, 80.00)

71.00 (66.00, 80.00)

0.0100b

74.05 ± 10.12

70.66 ± 11.14

0.0118a

Hypertension treatment (treated/untreated)

596 / 700

130 / 56

 < 0.0001c

200 / 225

43 / 19

0.0011c

HDL-C (mg/dL)

57.00 (46.00, 69.00)

48.00 (40.00, 60.00)

 < 0.0001b

58.00 (46.00, 70.00)

52.00 (41.00, 62.00)

0.0136b

LDL-C (mg/dL)

106.00 (86.00, 126.80)

89.50 (71.00, 112.30)

 < 0.0001b

108.00 ± 30.09

92.52 ± 31.68

0.0001a

TC (mg/dL)

188.00 (164.00, 214.00)

169.00 (142.00, 195.5)

 < 0.0001b

189.20 ± 34.78

171.10 ± 38.22

0.0002a

TG (mg/dL)

101.00 (73.00, 139.00)

125.00 (81.00, 161.30)

 < 0.0001b

99.00 (71.00, 133.50)

120.50 (82.00, 150.50)

0.0053b

  1. Data were showed as mean ± standard deviation or median (interquartile range)
  2. BMI Body mass index, FBG Fasting blood glucose, SBP Systolic blood pressure, DBP Diastolic blood pressure, HDL-C High-density lipoprotein cholesterol, LDL-C Low-density lipoprotein cholesterol, TC Total cholesterol, TG Triglycerides
  3. aStudent’s t test. bMann–Whitney U test. cChi-square test