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Fig. 6 | Clinical Epigenetics

Fig. 6

From: Identification of DNA methylation-regulated genes as potential biomarkers for coronary heart disease via machine learning in the Framingham Heart Study

Fig. 6

Feature importance in the LightGBM-based machine learning models and validation of hub genes in peripheral blood monocytes. A–C Feature importance in the methylation model, expression model and combination model quantized by Gini importance. D-F Feature importance in the methylation model, expression model and combination model based on SHAP values. G, H Methylation and expression levels of the five hub genes in monocytes from CHD patients and controls. I-K PCA plots based on the methylation data, expression data, integrated methylation and expression data of the five hub genes in monocytes from CHD patients and controls

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