Fig. 7From: Interpretation of the role of germline and somatic non-coding mutations in cancer: expression and chromatin conformation informed analysisMany trans-eQTLs are also cis-eQTLs. A SNP may first alter the expression level of a cis diffusible mediator, such as a transcription factor, which then alters the expression of the trans genes through altering the binding of the transcription factor to its binding sites near the downstream trans genesBack to article page