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Fig. 6 | Clinical Epigenetics

Fig. 6

From: Interpretation of the role of germline and somatic non-coding mutations in cancer: expression and chromatin conformation informed analysis

Fig. 6

Illustration of two different recurrence model. A Site-level recurrence model: three point mutations from three individual tumor samples are clustered on the same site, making it a hotspot of somatic mutations. B Gene-level recurrence model: three point mutations from three individual tumor samples are scattered on three different regulatory elements, but when spatial conformation is taken into account, those mutations converge on the same target gene. Figure is adapted from [175]

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