From: A blood DNA methylation biomarker for predicting short-term risk of cardiovascular events
Follow-up time | # Events | DNAmCVDscore | DNAmGrimAge | SCORE2 | MRS | SCORE2 + DNAmCVDscore | |||||
---|---|---|---|---|---|---|---|---|---|---|---|
AUC (95% CI) | Sensitivity; specificity | AUC (95% CI) | Sensitivity; specificity | AUC (95% CI) | Sensitivity; specificity | AUC (95% CI) | Sensitivity; specificity | AUC (95% CI) | Sensitivity; specificity | ||
18Â years | 160 | 0.525 (0.461; 0.589) | 0.477; 0.580 | 0.569 (0.505; 0.632) | 0.647; 0.482 | 0.749 (0.696; 0.803) | 0.719; 0.698 | 0.484 (0.420; 0.548) | 0.523; 0.500 | 0.753 (0.700; 0.807) | 0.732; 0.685 |
17Â years | 159 | 0.527 (0.463; 0.591) | 0.520; 0.553 | 0.562 (0.498; 0.626) | 0.669; 0.472 | 0.753 (0.700; 0.806) | 0.753; 0.671 | 0.516 (0.452; 0.580) | 0.545; 0.484 | 0.757 (0.704; 0.810) | 0.740; 0.689 |
16Â years | 158 | 0.527 (0.463; 0.591) | 0.513; 0.554 | 0.559 (0.496; 0.623) | 0.583; 0.572 | 0.751 (0.698; 0.805) | 0.718; 0.692 | 0.527 (0.463; 0.591) | 0.449; 0.610 | 0.756 (0.704; 0.809) | 0.705; 0.717 |
15Â years | 149 | 0.541 (0.477; 0.604) | 0.518; 0.577 | 0.560 (0.496; 0.623) | 0.681; 0.450 | 0.739 (0.684; 0.794) | 0.741; 0.671 | 0.536 (0.472; 0.600) | 0.509; 0.477 | 0.745 (0.691; 0.799) | 0.687; 0.732 |
14Â years | 139 | 0.567 (0.504; 0.630) | 0.483; 0.662 | 0.581 (0.518; 0.644) | 0.494; 0.662 | 0.730 (0.674; 0.786) | 0.705; 0.691 | 0.573 (0.509; 0.636) | 0.682; 0.475 | 0.741 (0.686; 0.796) | 0.688; 0.683 |
13Â years | 123 | 0.595 (0.531; 0.659) | 0.625; 0.537 | 0.592 (0.528; 0.656) | 0.526; 0.667 | 0.720 (0.663; 0.777) | 0.662; 0.699 | 0.595 (0.531; 0.659) | 0.531; 0.650 | 0.731 (0.676; 0.787) | 0.651; 0.740 |
12Â years | 111 | 0.596 (0.530; 0.662) | 0.529; 0.649 | 0.594 (0.529; 0.659) | 0.510; 0.694 | 0.709 (0.650; 0.768) | 0.588; 0.775 | 0.592 (0.525; 0.658) | 0.588; 0.613 | 0.718 (0.661; 0.775) | 0.598; 0.757 |
11Â years | 95 | 0.622 (0.554; 0.690) | 0.536; 0.705 | 0.618 (0.549; 0.686) | 0.568; 0.663 | 0.693 (0.630; 0.755) | 0.582; 0.758 | 0.610 (0.540; 0.680) | 0.536; 0.695 | 0.710 (0.651; 0.770) | 0.600; 0.737 |
10Â years | 84 | 0.622 (0.551; 0.693) | 0.580; 0.607 | 0.619 (0.548; 0.691) | 0.576; 0.631 | 0.700 (0.636; 0.765) | 0.550; 0.845 | 0.602 (0.530; 0.673) | 0.541; 0.667 | 0.721 (0.661; 0.781) | 0.554; 0.821 |
9Â years | 67 | 0.647 (0.571; 0.722) | 0.601; 0.612 | 0.645 (0.569; 0.721) | 0.649; 0.582 | 0.683 (0.611; 0.754) | 0.609; 0.746 | 0.623 (0.546; 0.700) | 0.581; 0.627 | 0.708 (0.642; 0.775) | 0.577; 0.731 |
8Â years | 55 | 0.687 (0.611; 0.762) | 0.569; 0.709 | 0.676 (0.601; 0.752) | 0.627; 0.673 | 0.692 (0.618; 0.766) | 0.623; 0.746 | 0.638 (0.554; 0.722) | 0.635; 0.618 | 0.732 (0.664; 0.800) | 0.612; 0.782 |
7Â years | 37 | 0.711 (0.626; 0.796) | 0.615; 0.703 | 0.707 (0.625; 0.789) | 0.554; 0.811 | 0.678 (0.587; 0.770) | 0.622; 0.703 | 0.668 (0.566; 0.770) | 0.669; 0.622 | 0.721 (0.641; 0.801) | 0.741; 0.649 |
6Â years | 28 | 0.778 (0.702; 0.854) | 0.673; 0.786 | 0.771 (0.688; 0.853) | 0.634; 0.821 | 0.753 (0.668; 0.839) | 0.686; 0.786 | 0.730 (0.616; 0.844) | 0.669; 0.750 | 0.803 (0.740; 0.867) | 0.676; 0.893 |
5Â years | 23 | 0.774 (0.695; 0.853) | 0.623; 0.826 | 0.773 (0.694; 0.851) | 0.634; 0.826 | 0.761 (0.665; 0.856) | 0.723; 0.783 | 0.735 (0.618; 0.852) | 0.688; 0.783 | 0.800 (0.741; 0.860) | 0.757; 0.783 |
4Â years | 16 | 0.823 (0.746; 0.899) | 0.799; 0.688 | 0.821 (0.736; 0.906) | 0.632; 0.938 | 0.785 (0.653; 0.917) | 0.722; 0.875 | 0.783 (0.649; 0.917) | 0.689; 0.875 | 0.830 (0.755; 0.906) | 0.773; 0.750 |
3Â years | 13 | 0.811 (0.720; 0.901) | 0.642; 0.846 | 0.806 (0.724; 0.888) | 0.652; 0.846 | 0.772 (0.620; 0.923) | 0.772; 0.846 | 0.762 (0.628; 0.896) | 0.768; 0.769 | 0.809 (0.726; 0.892) | 0.705; 0.846 |
2Â years | 7 | 0.851 (0.767; 0.935) | 0.799; 0.857 | 0.842 (0.745; 0.939) | 0.737; 0.857 | 0.751 (0.575; 0.926) | 0.656; 0.857 | 0.717 (0.562; 0.872) | 0.779; 0.571 | 0.863 (0.766; 0.960) | 0.766; 0.857 |