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Table 3 DNAm surrogates composing the DNAmCVD score

From: A blood DNA methylation biomarker for predicting short-term risk of cardiovascular events

Study

DNAm surrogate biomarker

DNAmCVDscore coefficient

Original biomarker/risk factor

This study

DNAmGlucose

0.0329

Blood glucose

This study

DNAmHDL

− 0.4473

Blood HDL cholesterol

This study

DNAmSBP

0.1420

Systolic blood pressure

This study

DNAmCRP

0.0276

Blood C-reactive protein

This study

DNAmPAI1

0.1679

Blood Plasminogen activator inhibitor 1

Gadd et al. 2022

DNAmSKR3

0.0362

Blood Serine/threonine-protein kinase receptor R3

Gadd et al. 2022

DNAmHGF

0.0371

Blood Hepatocyte growth factor

Colicino et al. 2021

DNAmLeadPatella

0.0402

Lead levels in Patella’s bone

Lu et al. 2019

DNAmGDF15

0.0947

Blood Growth Differentiation Factor 15

Lu et al. 2019

DNAmPACKYRS

0.1192

Smoking pack-years

  1. DNAmCVDscore is computed as a linear combination of standardised (mean = 0, variance = 1) DNAm surrogates with weights listed in the coefficient column. All biomarkers but DNAmHDL have positive coefficients (higher CVD risk associated with a higher value for the biomarker)