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Table 1 Demographic and clinical data from the Discovery and Replication Cohorts

From: Altered methylation pattern in EXOC4 is associated with stroke outcome: an epigenome-wide association study

 

Discovery

Replication

P value

GRECOS

BASICMAR

Subjects(n)

59

584

62

 

Sex

   

0.429

 Male, n (%)

49 (17%)

322 (55.2%)

32 (51.6%)

 

 Female, n (%)

10 (83%)

262 (44.8%)

30 (48.4%)

 

Age in years, median (IQR)

71 (15)

77 (14)

77 (9.5)

0.22

NIHSS at baseline, median (IQR)

3 (6.5)

5 (8)

15 (11.5)

 < 2.2 × 10–16*

NIHSS at discharge, median (IQR)

1 (2)

3 (6)

4 (12)

2.62 × 10–06*

ΔNIHSS, median (IQR)

1 (4)

1 (4)

5 (11)

6.6 × 10–04*

mRS 90 days, median (IQR)

1 (3)

2 (3)

1 (3)

5.4 × 10–04*

Presence of HTN, n (%)

37 (62.7%)

236 (40.1%)

40 (64.5%)

1.04 × 10–03*

Smoking, n (%)

13 (22%)

168 (28.8%)

6 (9.67%)

3 × 10–07*

Presence of AF, n (%)

3 (5%)

201 (34.4%)

25 (40.3%)

2.86 × 10–02*

Presence of DM, n (%)

17 (28.8%)

421 (72.1%)

8 (12.9%)

9.5 × 10–11*

Treatment with rtPA, n (%)

9 (15.3%)

91 (15.6%)

53 (85.5%)

 < 2.2 × 10–16*

TOAST

CES, n (%)

0 (0%)

231 (53.9%)

29 (46.7%)

 < 2.2 × 10–16*

LAS, n (%)

SVS, n (%)

Und, n (%)

Other, n (%)

NA

26 (44.1%)

11 (18.6%)

21 (35.6%)

1 (1.7%)

0 (0%)

153 (39.6%)

194 (33.2%)

4 (0.7%)

2 (0.34%)

0 (0%)

17 (27.4%)

0 (0%)

13 (2.1%)

0 (0%)

3 (4.8%)

  1. Main clinical characteristics of patients included in the analysis from the Discovery and Replication Cohorts. P value column indicates differences for each variable between Discovery (both GRECOS and BASICMAR together) and Replication Cohorts
  2. IQR interquartile range; ΔNIHSS = NIHSS at baseline – NIHSS at discharge; HTN: hypertension; AF atrial fibrillation; DM: diabetes mellitus; CES cardioembolic stroke; LAS large artery stroke; SVS small vessel stroke; und undetermined stroke
  3. *Statistically significant p values for differences between cases and controls. NA: not available