Table 5 Other DNA methylation-based liquid biopsy for LC
Purpose | Genes | Cases | Controls | Sensitivity/specificity | Samples | Methods | References |
|---|---|---|---|---|---|---|---|
Diagnosis | CpG sites | 15 | 5 | –/– | CTC | LCM-μWGBS and PCR | [85] |
Subtype | CpG sites | 884 | 154 | –/– | CTC | 450 K Methylation BeadChip and WGBS | [86] |
Diagnosis | SOX17/HOXA9/CDO1/TAC1 | 74 | 27 | 93.0/30.0% | Urine | qMSP | [87] |
Diagnosis | CDO1/SOX17/TAC1 | 23 | 60 | –/– | Urine | qMSP | [88] |
Prognosis | MGMT/BRCA1/RARβ/p16/INK4a | 30 | 0 | –/– | Pleural effusion | MSP | [89] |