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Table 2 The involvement of the single gene in LC

From: Liquid biopsies based on DNA methylation as biomarkers for the detection and prognosis of lung cancer

Gene

The involvement of the gene in LC

References

B3GAT2

–

–

BCAR1

B3GAT2 promotes the formation and immune evasion of CTCs in LUAD by triggering EMT via RAC1 signaling and up-regulating CD274 expression by shuttling BRD4-S into the nucleus

[52]

HOPX

ΜicroRNA-421 promotes the progression of NSCLC by targeting HOPX and regulating the Wnt/β-catenin signaling pathway

[53]

HOXD11

–

–

MIR1203

MIR1203 level is negatively regulated by LINC00632 to accelerate lymph node metastasis and distant metastasis of NSCLC

[54]

MYL9

Low MYL9 expression may be relevant to the development and metastasis of NSCLC

[55]

SLC9A3R2

–

–

SYT5

–

–

VTRNA1-3

–

–

HLF

Genetic deletion and methylation lead to down expression of HLF, thus accelerating anaerobic metabolism to promote the growth of NSCLC cells by activating NF-κB/p65 signaling through disrupting translocation of PPARα and PPARγ

[56]