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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Liquid biopsies based on DNA methylation as biomarkers for the detection and prognosis of lung cancer

Fig. 1

Formation of DNA methylation and its regulation of gene expression. A Process of DNA methylation. DNA methylation usually happens in CpG islands by adding a methyl group, provided by S-adenosylmethionine (SAM), to the carbon-5 position of a cytosine. This process is catalyzed by DNA methyltransferases (DNMTs). B DNA methylation of gene promoters. Unmethylated CpGs result in gene activation. Methylated CpGs lead to gene silencing

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Clinical Epigenetics

ISSN: 1868-7083

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