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Fig. 5 | Clinical Epigenetics

Fig. 5

From: PDCD5 inhibits progression of renal cell carcinoma by promoting T cell immunity: with the involvement of the HDAC3/microRNA-195-5p/SGK1

Fig. 5

RCC proliferation is restrained, and T cell activation is stimulated by PDCD5 via the HDAC3/miR-195-5p/SGK1 axis. A The protein expression of PDCD5, HDAC3, and SGK1 in A498 cells normalized to GAPDH determined by Western blot analysis. B miR-195-5p expression in A498 cells determined by RT-qPCR. C A498 cell proliferation detected by EdU assay. D IFN-γ+ T cell proportion and CD3+ T cell proliferation detected by flow cytometry. E The expression of IFN-γ released from CD3+ T cells determined by ELISA. *p < 0.05 between the two groups. The results were measurement data and expressed as mean ± standard deviation. The results were collected from at least 3 independent cell experiments

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Clinical Epigenetics

ISSN: 1868-7083

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