Fig. 3

Genes associated with 5hmC alterations predict clinical outcome in genitourinary cancers. A Scatter plots showing the positive correlation between 5hmC alterations and mRNA expression changes in genitourinary cancers. B–D Box plots displaying the expression of hyper-DhMR associated genes with the most transcriptional changes compared to normal tissues in the TCGA KIRC (B), PRAD (C) and BLCA (D) cohorts. P values were determined by the Student’s t test. ****P < 0.0001; ***P < 0.001; **P < 0.01;*P < 0.05. E–G Kaplan–Meier plots of the relationship between patient overall survival, progression-free survival and hyper-hydroxymethylated signature scores within the TCGA KIRC (E), PRAD (F) and BLCA (G) cohorts. Patients were stratified by the score median. P values were produced using log rank test