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Table 4 DNAm in individual CpG sites as predictors of aeroallergen sensitization (H1). Replication of validated CpGs (Table 3) in BAMSE

From: DNA methylation and aeroallergen sensitization: The chicken or the egg?

HMA Method Mediator [CpG (UCSC/nearest gene - UCSC Group)] Indirect effect
[95% CI]
Direct effect
[95% CI]
Total effect
[95% CI]
Prop.Med
[95% CI]
mQTL
(Hawea)
A. DNAm at eight and sensitization measured at 16 years
(i) Maternal smoking during pregnancy
DACT cg26851984
(/RP11-772E11.1)
0.004
[− 0.012; 0.025]
− 0.035
[− 0.193; 0.134]
− 0.031
[− 0.189; 0.138]
− 0.001
[− 1.667; 1.304]
58
(iii) PRS for any allergies
HIMA cg19310430
(C11orf45 - 5'UTR)
0.000
[− 0.004; 0.004]
0.101
[0.048; 0.154]
0.101
[0.050; 0.154]
0.000
[− 0.041; 0.050]
 
  1. CpGs cg17992705, cg11329030 and cg04684486 are only available on the EPIC array and thus not available in BAMSE, which used the 450K array.
  2. aNo mQTLs from Gaunt et al. were matched to the respective CpGs