Table 4 DNAm in individual CpG sites as predictors of aeroallergen sensitization (H1). Replication of validated CpGs (Table 3) in BAMSE
From: DNA methylation and aeroallergen sensitization: The chicken or the egg?
HMA Method | Mediator [CpG (UCSC/nearest gene - UCSC Group)] | Indirect effect [95% CI] | Direct effect [95% CI] | Total effect [95% CI] | Prop.Med [95% CI] | mQTL (Hawea) |
|---|---|---|---|---|---|---|
A. DNAm at eight and sensitization measured at 16 years | ||||||
(i) Maternal smoking during pregnancy | ||||||
DACT | cg26851984 (/RP11-772E11.1) | 0.004 [− 0.012; 0.025] | − 0.035 [− 0.193; 0.134] | − 0.031 [− 0.189; 0.138] | − 0.001 [− 1.667; 1.304] | 58 |
(iii) PRS for any allergies | ||||||
HIMA | cg19310430 (C11orf45 - 5'UTR) | 0.000 [− 0.004; 0.004] | 0.101 [0.048; 0.154] | 0.101 [0.050; 0.154] | 0.000 [− 0.041; 0.050] | |