Table 3 DNAm in individual CpG sites as predictors of aeroallergen sensitization (H1). Displayed CpGs were significantly validated in the causal mediation analysis (FDR < 0.05)
From: DNA methylation and aeroallergen sensitization: The chicken or the egg?
HMA Method | Mediator [CpG (UCSC/nearest gene—UCSC Group)] | Indirect effect [95% CI] | Direct effect [95% CI] | Total effect [95% CI] | Prop.Med [95% CI] | mQTL (Hawe et al.a) |
|---|---|---|---|---|---|---|
A. DNAm at six years and sensitization measured at ten years | ||||||
(i) Maternal smoking during pregnancy | ||||||
DACT | cg26851984 (/RP11-772E11.1) | 0.139 [0.050; 0.242] | − 0.025 [− 0.226; 0.182] | 0.114 [− 0.124; 0.328] | 0.811 [− 7.782; 8.513] | 58 |
HIMA | cg17992705 (ATXN2L - ExonBnd) | − 0.108 [− 0.193; − 0.041] | 0.217 [0.017; 0.397] | 0.109 [− 0.102; 0.315] | − 0.601 [− 11.384; 14.469] | |
(ii) Family history of allergic disease (both parents allergic) | ||||||
HIMA | cg11329030 (/ATP6V1E1P1) | 0.095 [0.040; 0.158] | 0.079 [− 0.025; 0.193] | 0.174 [0.060; 0.280] | 0.547 [0.218; 1.349] | |
(iii) PRS for any allergies | ||||||
HIMA | cg04684486 (SLC31A2 - TSS200) | 0.020 [0.004; 0.042] | 0.019 [− 0.043; 0.082] | 0.040 [− 0.026; 0.103] | 0.390 [− 2.851; 6.302] | |
B. DNAm at ten years and sensitization measured at 15 years | ||||||
(iii) PRS for any allergies | ||||||
HIMA | cg19310430 (C11orf45 - 5'UTR) | 0.063 [0.026; 0.105] | 0.036 [− 0.036; 0.110] | 0.099 [0.019; 0.179] | 0.632 [0.208; 1.910] | |