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Table 3 DNAm in individual CpG sites as predictors of aeroallergen sensitization (H1). Displayed CpGs were significantly validated in the causal mediation analysis (FDR < 0.05)

From: DNA methylation and aeroallergen sensitization: The chicken or the egg?

HMA Method Mediator [CpG (UCSC/nearest gene—UCSC Group)] Indirect effect
[95% CI]
Direct effect
[95% CI]
Total effect
[95% CI]
Prop.Med
[95% CI]
mQTL
(Hawe et al.a)
A. DNAm at six years and sensitization measured at ten years
(i) Maternal smoking during pregnancy
DACT cg26851984
(/RP11-772E11.1)
0.139
[0.050; 0.242]
− 0.025
[− 0.226; 0.182]
0.114
[− 0.124; 0.328]
0.811
[− 7.782; 8.513]
58
HIMA cg17992705
(ATXN2L - ExonBnd)
− 0.108
[− 0.193; − 0.041]
0.217
[0.017; 0.397]
0.109
[− 0.102; 0.315]
− 0.601
[− 11.384; 14.469]
 
(ii) Family history of allergic disease (both parents allergic)
HIMA cg11329030
(/ATP6V1E1P1)
0.095
[0.040; 0.158]
0.079
[− 0.025; 0.193]
0.174
[0.060; 0.280]
0.547
[0.218; 1.349]
 
(iii) PRS for any allergies
HIMA cg04684486
(SLC31A2 - TSS200)
0.020
[0.004; 0.042]
0.019
[− 0.043; 0.082]
0.040
[− 0.026; 0.103]
0.390
[− 2.851; 6.302]
 
B. DNAm at ten years and sensitization measured at 15 years
(iii) PRS for any allergies
HIMA cg19310430
(C11orf45 - 5'UTR)
0.063
[0.026; 0.105]
0.036
[− 0.036; 0.110]
0.099
[0.019; 0.179]
0.632
[0.208; 1.910]
 
  1. CpG sites that were identified as mediators in at least one high-dimension mediation analysis (HMA) method (HIMA or DACT) and validated in causal mediation analysis (significant indirect effect) are presented.
  2. aNo mQTLs from Gaunt et al. [38] were matched to the respective CpGs