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Table 2 Significant mediation (FDR < 0.05) between family history as exposure and MRS, mediated by aeroallergen sensitization measured (H2)

From: DNA methylation and aeroallergen sensitization: The chicken or the egg?

Outcome Indirect effect
[95% CI]
Direct effect
[95% CI]
Total effect
[95% CI]
Prop.Med
[95% CI]
(A) Sensitization at 6 and DNAm measured at 10 years
(ii) Family history of allergic disease (both parents allergic)
Chen2017
(IgE)
0.081
[0.020; 0.160]
0.107
[− 0.122; 0.326]
0.188
[− 0.042; 0.425]
0.397
[− 2.116; 4.516]
Everson2015
(Atopy)
0.075
[0.016; 0.151]
0.136
[− 0.096; 0.356]
0.211
[− 0.020; 0.447]
0.337
[− 1.562; 2.894]
Peng2019
(Aeroallergen)
0.059
[0.009; 0.123]
0.012
[− 0.202; 0.216]
0.071
[− 0.140; 0.289]
0.355
[− 8.136; 5.016]
Reese2019
(Asthma)
0.073
[0.017; 0.145]
0.064
[− 0.149; 0.268]
0.137
[− 0.077; 0.357]
0.441
[− 3.563; 4.141]
Xu2021
(Allergy)
0.060
[0.014; 0.119]
− 0.008
[− 0.179; 0.154]
0.052
[− 0.119; 0.227]
0.463
[− 7.445; 7.536]
Zhang2019
(Atopy)
0.076
[0.019; 0.148]
0.023
[− 0.179; 0.216]
0.099
[− 0.105; 0.307]
0.496
[− 6.537; 5.902]
  1. No significant associations were found for (i) maternal smoking or (iii) PRS for any allergies