Table 2 Significant mediation (FDR < 0.05) between family history as exposure and MRS, mediated by aeroallergen sensitization measured (H2)
From: DNA methylation and aeroallergen sensitization: The chicken or the egg?
Outcome | Indirect effect [95% CI] | Direct effect [95% CI] | Total effect [95% CI] | Prop.Med [95% CI] |
|---|---|---|---|---|
(A) Sensitization at 6 and DNAm measured at 10 years | ||||
(ii) Family history of allergic disease (both parents allergic) | ||||
Chen2017 (IgE) | 0.081 [0.020; 0.160] | 0.107 [− 0.122; 0.326] | 0.188 [− 0.042; 0.425] | 0.397 [− 2.116; 4.516] |
Everson2015 (Atopy) | 0.075 [0.016; 0.151] | 0.136 [− 0.096; 0.356] | 0.211 [− 0.020; 0.447] | 0.337 [− 1.562; 2.894] |
Peng2019 (Aeroallergen) | 0.059 [0.009; 0.123] | 0.012 [− 0.202; 0.216] | 0.071 [− 0.140; 0.289] | 0.355 [− 8.136; 5.016] |
Reese2019 (Asthma) | 0.073 [0.017; 0.145] | 0.064 [− 0.149; 0.268] | 0.137 [− 0.077; 0.357] | 0.441 [− 3.563; 4.141] |
Xu2021 (Allergy) | 0.060 [0.014; 0.119] | − 0.008 [− 0.179; 0.154] | 0.052 [− 0.119; 0.227] | 0.463 [− 7.445; 7.536] |
Zhang2019 (Atopy) | 0.076 [0.019; 0.148] | 0.023 [− 0.179; 0.216] | 0.099 [− 0.105; 0.307] | 0.496 [− 6.537; 5.902] |