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Table 1 Description of total sample of LISA participants included in this study

From: DNA methylation and aeroallergen sensitization: The chicken or the egg?

  Time window A
(6 and 10 years)
Time window B
(10 and 15 years)
Total sample size—N 234 227
Confounder   
 Male sex—N (%) [Nmiss] 135 (57.7%) [0] 131 (57.7%) [0]
 Exact age at baseline—Mean (sd) [Nmiss] 6.1 (0.2) [0] 10.2 (0.1) [0]
 Exact age at follow-up—Mean (sd) [Nmiss] 10.2 (0.1) [0] 15.2 (0.2) [52]
 Blood taken in allergy season at baselineN (%) [Nmiss] 158 (67.5%) [0] 116 (51.1%) [0]
 Blood taken in allergy season at follow-upN (%) [Nmiss] 124 (53%) [0] 90 (51.4%) [52]
 BMI measured at baseline—Mean (sd) [Nmiss] 15.3 (1.3) [1] 17.0 (2.5) [1]
 BMI measured at follow-up—Mean (sd) [Nmiss] 16.9 (2.5) [1] 20.3 (2.8) [59]
 High parental education—N (%) [Nmiss] 186 (80.2%) [2] 181 (80.4%) [2]
 N02 at birth address—Mean (sd) [Nmiss] 21.4 (6.1) [1] 21.2 (5.5) [1]
Exposures   
 (i) Maternal smoking during pregnancy—N (%) [Nmiss] 17 (7.5%) [7] 16 (7.2%) [6]
 (ii) At least one parent allergic—N (%) [Nmiss] 151 (64.5%) [0] 148 (65.2%) [0]
 (iii) PRS—Mean (sd) [Nmiss] 0.2 (1.0) [12] 0.2 (0.9) [11]
Outcome   
 Sensitized at baselineN (%) [Nmiss] 74 (31.6%) [0] 101 (44.5%) [0]
 Sensitized at follow-upN (%) [Nmiss] 105 (44.9%) [0] 84 (50.3%) [60]
  1. Baseline is defined as the first time point of the model (six or ten) and follow-up as the second (ten or 15, respectively). The sample sizes for the mediation models with different exposures were as followed: Hypothesis 1A—NMaternalSmoking = 215, NFamilyHistory = 198, NPRS = 211; Hypothesis 1B—NMaternalSmoking = 163, NFamilyHistory = 154, NPRS = 158; Reversed models for Hypothesis 2A (Exposure–Sensitization–DNAm)—NMaternalSmoking = 216, NFamilyHistory = 222, NPRS = 212. See also Additional file 1: Figure S1