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Table 2 Comparisons of MEF2C-AS1 methylation in lesion tissues from patients at different stages during colorectal carcinogenesis

From: Hypermethylation of tumor suppressor lncRNA MEF2C-AS1 frequently happened in patients at all stages of colorectal carcinogenesis

CpG site

NAA

AA

CRC

p valuea

AA vs. NAA

CRC vs. NAA

CRC vs. AA

N

β

N

β

N

β

 

Δβ

p valueb

Δβ

p valueb

Δβ

p valueb

CpG_1

80

0.16

79

0.24

283

0.23

0.009

0.08

0.049

0.07

0.008

− 0.02

1.000

CpG_3

80

0.19

79

0.29

283

0.27

0.001

0.10

0.008

0.08

0.001

− 0.02

1.000

CpG_4.5.6

73

0.16

75

0.23

277

0.23

0.014

0.07

0.137

0.07

0.011

0.01

1.000

CpG_7

80

0.18

79

0.25

282

0.24

0.087

0.07

–

0.06

–

− 0.01

–

CpG_8

80

0.11

79

0.21

283

0.18

 < 0.001

0.10

0.002

0.07

 < 0.001

− 0.03

1.000

CpG_9.10

74

0.25

76

0.33

276

0.33

0.012

0.08

0.079

0.08

0.010

0.00

1.000

CpG_11

80

0.15

79

0.25

283

0.23

0.003

0.10

0.016

0.08

0.004

− 0.02

1.000

CpG_12

80

0.20

79

0.29

283

0.24

0.021

0.09

0.021

0.04

0.084

− 0.04

0.714

CpG_13

80

0.16

79

0.27

283

0.22

0.012

0.10

0.011

0.05

0.069

− 0.05

0.515

CpG_14.15

80

0.17

79

0.27

283

0.24

0.011

0.10

0.022

0.07

0.021

− 0.03

1.000

CpG_16

80

0.19

79

0.29

283

0.27

0.001

0.10

0.008

0.08

0.001

− 0.02

1.000

CpG_17

70

0.14

73

0.19

263

0.17

0.135

0.05

-

0.03

-

− 0.02

-

CpG_18

80

0.13

79

0.21

283

0.20

0.005

0.08

0.021

0.07

0.006

− 0.01

1.000

CpG_21

80

0.24

79

0.29

283

0.28

0.429

0.05

–

0.03

–

− 0.02

–

CpG_22

79

0.26

79

0.32

283

0.27

0.075

0.06

–

0.01

–

− 0.05

–

CpG_23

80

0.22

79

0.33

283

0.28

0.003

0.11

0.003

0.06

0.025

− 0.05

0.400

CpG_25

80

0.22

79

0.33

283

0.28

0.003

0.11

0.003

0.06

0.025

− 0.05

0.400

CpG_26

80

0.21

78

0.34

283

0.30

0.001

0.12

0.002

0.09

0.003

− 0.04

1.000

Mean

80

0.19

79

0.28

283

0.25

0.012

0.09

0.020

0.06

0.025

− 0.03

1.000

  1. p < 0.05 was considered statistically significant
  2. AA, advanced adenoma; CRC, colorectal cancer; NAA, non-advanced adenoma
  3. aKruskal–Wallis test
  4. bPost hoc Dunn’s test