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Table 1 Association between different stages during or before pregnancy and exposure to six air pollutants

From: Integrated single-cell RNA-seq and DNA methylation reveal the effects of air pollution in patients with recurrent spontaneous abortion

Air pollutants

Stage

Unadjusted

Adjusted

OR (95% CI)

P value

OR (95% CI)

P value

PM2.5

First trimester

1.038 (1.001, 1.076)

0.043

1.035 (0.999, 1.073)

0.060

3 months before pregnancy

1.018 (0.992, 1.044)

0.181

1.023 (0.995, 1.051)

0.104

6 months before pregnancy

0.992 (0.969, 1.016)

0.510

0.996 (0.972, 1.021)

0.758

1 year before pregnancy

1.070 (1.016, 1.127)

0.010

1.080 (1.023, 1.140)

0.006

PM10

First trimester

1.052 (1.016, 1.089)

0.004

1.051 (1.015, 1.088)

0.005

3 months before pregnancy

1.002 (0.988, 1.016)

0.805

1.005 (0.990, 1.020)

0.538

6 months before pregnancy

0.993 (0.979, 1.008)

0.384

0.996 (0.981, 1.011)

0.608

1 year before pregnancy

1.028 (1.001, 1.055)

0.045

1.033 (1.004, 1.062)

0.024

CO

First trimester

1.004 (1.001, 1.006)

0.003

1.003 (1.001, 1.006)

0.005

3 months before pregnancy

1.001 (0.999, 1.002)

0.390

1.001 (0.999, 1.003)

0.254

6 months before pregnancy

0.999 (0.998, 1.000)

0.120

0.999 (0.998, 1.001)

0.214

1 year before pregnancy

1.005 (1.001, 1.008)

0.007

1.005 (1.002, 1.009)

0.005

NO2

First trimester

1.013 (0.970, 1.057)

0.564

1.007 (0.964, 1.052)

0.759

3 months before pregnancy

0.972 (0.926, 1.020)

0.244

0.977 (0.930, 1.026)

0.353

6 months before pregnancy

0.939 (0.896, 0.984)

0.009

0.943 (0.899, 0.990)

0.018

1 year before pregnancy

2.231 (1.114, 4.469)

0.024

2.174 (1.085, 4.356)

0.029

SO2

First trimester

1.134 (1.029, 1.250)

0.011

1.135 (1.029, 1.251)

0.011

3 months before pregnancy

1.017 (0.981, 1.054)

0.365

1.023 (0.985, 1.062)

0.242

6 months before pregnancy

0.989 (0.954, 1.026)

0.571

0.995 (0.958, 1.034)

0.814

1 year before pregnancy

1.127 (1.048, 1.213)

0.001

1.137 (1.053, 1.229)

0.001

O3

First trimester

0.980 (0.969, 0.992)

0.001

0.981 (0.970, 0.993)

0.002

3 months before pregnancy

1.004 (0.990, 1.019)

0.554

1.002 (0.988, 1.017)

0.761

6 months before pregnancy

1.011 (0.999, 1.023)

0.084

1.009 (0.997, 1.022)

0.157

1 year before pregnancy

0.991 (0.941, 1.044)

0.729

0.982 (0.929, 1.037)

0.504

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Clinical Epigenetics

ISSN: 1868-7083

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