Fig. 6
From: Genomic targets and selective inhibition of DNA methyltransferase isoforms
Inhibition of DNMTΔ3B4 by caffeic acid. A Changes in global methylation (%), measured by LINE-1 assay, in response to exposure to 0, 100 and 200 µM caffeic acid in cell lines expressing seven DNMT isoforms. B Changes in methylation at cg25843713 (top) and cg04458645 (bottom) in response to caffeic acid exposure. C Changes in methylation at two loci uniquely methylated by DNMTΔ3B4 (cg07504154, left; cg22976313, right) in response to caffeic acid exposure. Methylation in control cells (black) and those overexpressing DNMT3L (grey) and DNMTΔ3B4 (red) are displayed. D Methylase activity of DNMTΔ3B4 in the presence of 0–300 µM caffeic acid. Data are presented as means ± SD