Fig. 2
From: Genomic targets and selective inhibition of DNA methyltransferase isoforms
Characterisation of changes in DNA methylation in response to DNMT isoform overexpression. A Number of CpG sites displaying gains (left, purple) and losses (right, green) of Δβ > 0.4 (dark purple/green), Δβ > 0.3 (medium purple/green) and Δβ > 0.2 (light purple/green) by DNMT isoform. B Frequency of gains of Δβ > 0.2 (purple) and losses of Δβ < − 0.2 (green) across all isoform-overexpressing cell lines by methylation levels in control cells. C Number of CpG sites displaying gains of Δβ > 0.2 mapping to CpG islands, shores, shelves and open seas by DNMT isoform. D Heatmap displaying methylation at loci displaying gains of methylation of Δβ > 0.3 in response to expression of one or more isoforms