Fig. 9
From: Epigenetic tumor heterogeneity in the era of single-cell profiling with nanopore sequencing
HEL308—helicase as motor protein translocating ssDNA A shows the mechanism and B Domain organization and motions of HEL308. The two (recombination protein A) RecA 1 and 2 domains compose the motor part; here, ATP binds between them and drives or rectifies the mechanochemical cycle, and the auxiliary ratchet domain makes several contacts with ssDNA and may offer determinants of the potential sequence specificity [159, 160]. Image adapted from [159]