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Fig. 6 | Clinical Epigenetics

Fig. 6

From: JIB-04, a histone demethylase Jumonji C domain inhibitor, regulates phenotypic switching of vascular smooth muscle cells

Fig. 6

JIB-04 regulated autophagy-related SQSTM1 expression by H3K36 methylation. A-B. Gene Set Enrichment Analysis (GSEA) and KEGG enrichment analysis showed autophagy and autophagy-related pathway changes in the JIB-04 group compared to the DMSO group. C. Differentially expressed genes in the autophagy pathway are shown in the heatmap. D-E. Protein levels of phosphorylated AMPKα (p-AMPKα) and phosphorylated mTOR (p-mTOR) were determined by western blotting (n = 4 per group). β-Actin served as a loading control. F. GSEA showed the response of HASMCs to glucose and amino acid starvation in the JIB-04 vs. DMSO group. *P < 0.05, **P < 0.01

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Clinical Epigenetics

ISSN: 1868-7083

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