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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Integrated multi-omics analyses reveal that BCAM is associated with epigenetic modification and tumor microenvironment subtypes of clear cell renal cell carcinoma

Fig. 1

BCAM mRNA and protein expression was lower in RCC tissues than in normal kidney tissues. A BCAM mRNA expression in tumor and normal tissues from pan-cancer data of The Cancer Genome Atlas (TCGA). *p < 0.05, **p < 0.01, ***p < 0.001. B BCAM mRNA expression in tumor and normal tissues from ccRCC, pRCC and chRCC obtained from 6 external datasets, including Higgins Renal, Gumz Renal, Beroukhim Renal, Yusenko Renal, Lenburg Renal and Jones Renal. C BCAM mRNA expression in tumor and normal tissues from ccRCC obtained from Gene Expression Omnibus (GEO) database, including GSE53757, GSE40435 and GSE66272. ****p < 0.0001. D Representative microphotographs of BCAM immunohistochemical staining in normal kidney tissue and ccRCC tissue by IHC. E BCAM mRNA expression in the single-cell-type clusters identified in normal kidney tissues. F BCAM protein expression in tumor and adjacent normal tissues from 6 patients in West China Hospital cohort by immunoblotting. The normalized data after quantitative analysis were shown on the right. **p < 0.01. G BCAM protein expression in tumor and normal tissues from ccRCC data of Clinical Proteomic Tumor Analysis Consortium (CPTAC). ***p < 0.001

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