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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Distinct modulation of IFNγ-induced transcription by BET bromodomain and catalytic P300/CBP inhibition in breast cancer

Fig. 2

IRF1 binding drives de novo enhancer remodeling. A Binding of IRF1 by ChIP-seq to IFNγ-induced loci. B Binding of P300 by ChIP-seq to IFNγ-induced loci. C Chromatin accessibility by ATAC-seq at IFNγ-induced loci. D Correlation in IRF1 and P300 recruitment at sites demonstrating increased ATAC-seq signal. E Log2 fold-change in ATAC-seq signal at promoters and enhancers following IFNγ stimulation. F Acetylation of H3K27 by ChIP-seq at IFNγ-induced loci. G Genes associated with super-enhancers in IFNγ stimulated or control AT3 cells. H Core CRC in IFNγ-stimulated cells (new IFNγ-dependent nodes colored red). I Binding of BRD4 by ChIP-seq to IFNγ-induced loci. J Binding of RNAPII by ChIP-seq to IFNγ-induced loci. K Tri-methylation of H3K4me3 by ChIP-seq at IFNγ-induced loci. L Histone modifications and RNAPII occupancy at constitutively expressed, IFNγ-induced, or non-expressed loci in AT3 cells. M Model for epigenetic activation of IFNγ stimulated genes. ****p < 0.0001, Mann–Whitney U test

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