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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Identification of clinical implications and potential prognostic models of chromatin regulator mutations in multiple myeloma

Fig. 3

The correlation between chromosome abnormalities and gene mutations. a The increased mutation rates of EP300 are associated with copy number gains of 1q21. b Patients with del(17p) have more mutations of TP53. c Mutation rates of FGFR3 increase in patients with t(4; 14). d Patients with del(17p) (n = 17) present shorter PFS compared to patients without del(17p) (n = 119), but this does not reach statistical significance. e Patients with both del(17p) and TP53 mutations present the worst PFS compared to patients with only one of them. Patients with none of del(17p) or TP53 mutations have the longest PFS. f Patients with del(17p) (n = 17) have shorter OS compared to patients without del(17p) (n = 119). g Patients with both del(17p) and TP53 mutations present the worst OS compared to patients with only one of them. Patients with none of del(17p) or TP53 mutations have the longest OS

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Clinical Epigenetics

ISSN: 1868-7083

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