Table 1 Confusion matrix of prediction performance of random forest model using 10 CRC-specific methylation CpG sites in distinguishing CRC from normal samples
Validation dataset | TCGA | GSE42752 | GSE48684 | GSE101764 |
|---|---|---|---|---|
Accuracy (95% CI) | 0.936 (0.909, 0.957) | 0.857 (0.746, 0.933) | 0.857 (0.775, 0.918) | 0.943 (0.907, 0.968) |
Balanced accuracy | 0.965 | 0.869 | 0.839 | 0.938 |
Sensitivity | 0.929 | 0.909 | 0.922 | 0.902 |
Specificity | 1.000 | 0.829 | 0.756 | 0.973 |
Kappa | 0.728 | 0.701 | 0.693 | 0.882 |