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Table 4 Methylation levels in leukocytes of ELITE participants at CpGs previously associated with atherosclerosis

From: Effect of menopausal hormone therapy on methylation levels in early and late postmenopausal women

Tissue

CpG

aChr:pos

Nearest Gene

Early/Placebo (n = 48)

Early/Treatment (n = 48)

Late/Placebo (n = 42)

Late/Treatment (n = 48)

bP-int

Aortic plaque

cg07608848

2:1,647,185

PXDN

0.4

0.1

0.1

0.2

0.43

Blood

cg23079012

2:8,343,662

LINC00299

− 0.2

0.3

0.2

0.1

0.66

Blood

cg21566642

2:233,284,613

ALPI

− 0.7

0.3

0.1

0.01

0.08

Blood

cg03358636

3:197,473,958

RUBCN

0.5

1.3

− 0.4

0.1

0.73

Blood/Carotid plaque

cg12806681

5:368,346

AHRR

0.1

0.1

0.3

0.3

0.82

Blood

cg23916896

5:368,756

AHRR

1.0

0.9

0.1

0.7

0.16

Blood/Carotid plaque

cg05575921

5:373,378

AHRR

− 0.1

− 0.2

0.6

− 0.2

0.63

Blood

cg26703534

5:377,358

AHRR

0.5

0.1

− 0.6

− 0.3

0.81

Blood

cg21161138

5:399,312

AHRR

0.6

0.1

− 0.5

− 0.1

0.97

Aortic plaque

cg23979631

7:27,142,427

HOXA2

0.2

1.0

0.0

0.0

0.36

Aortic plaque

cg19816811

7:27,188,364

HOXA6

1.0

0.7

0.1

− 0.5

0.28

Aortic plaque

cg03217995

7:27,203,430

HOXA9

3.2

2.1

− 1.4

0.8

0.45

Aortic plaque

cg16913789

7:27,204,005

HOXA9

0.8

− 0.2

− 0.1

− 0.2

0.37

Aortic plaque

cg25188395

7:27,204,052

HOXA9

0.6

0.8

− 0.2

0.9

0.70

Aortic plaque

cg17466857

7:27,225,528

HOXA11AS

0.1

0.0

− 0.1

0.2

0.03

Aortic plaque

cg01419713

8:42,038,135

PLAT

0.0

− 1.0

0.8

0.2

0.49

Blood

cg03450842

10:80,834,947

ZMIZ1

0.3

0.8

− 0.9

− 0.2

0.26

Blood

cg11660018

11:86,510,915

OR7E2P

0.2

0.9

− 0.4

0.3

0.16

Blood

cg03371962

12:1,772,275

MIR3649

0.6

0.8

0.1

− 0.5

0.87

Aortic plaque

cg23395715

12:54,369,514

HOXC11

0.8

0.6

0.9

0.7

0.68

Aortic plaque

cg02384661

12:54,369,638

HOXC11

0.3

0.0

− 0.2

0.3

0.47

Aortic plaque

cg03146625

12:54,448,729

HOXC4

1.1

1.9

0.3

1.8

0.42

Aortic plaque

cg15648389

12:54,448,769

HOXC4

2.5

0.9

0.9

2.5

0.48

Blood/Carotid plaque

cg05284742

14:93,552,080

ITPK1

0.2

1.2

0.2

− 0.2

0.96

Blood

cg17295878

17:77,924,665

TBC1D16

0.1

− 0.3

− 0.2

0.1

0.01

Blood

cg03636183

19:17,000,537

F2RL3

0.4

0.5

1.0

− 0.5

0.80

  1. Data are shown as the mean change in methylation levels (%) between baseline and 36 months after treatment (calculated as post–pre) for the four groups of women
  2. aChromosome and position (basepair) are based on build 37 (hg19) of the human genome reference sequence
  3. bp-values are derived from tests of interaction between time-since-menopause and HT using m-values for methylation, with adjustment for age, ethnicity, and estimated blood cell fractions
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Clinical Epigenetics

ISSN: 1868-7083

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