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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Effect of menopausal hormone therapy on methylation levels in early and late postmenopausal women

Fig. 1

Miami plot of EWAS results for association of methylation levels with smoking. Methylation levels at a CpG site on chromosome 5 (cg05575921) were significantly associated with smoking at baseline (top panel) and 36 months after hormone treatment (bottom panel). Genome-wide methylation was assessed across 748,567 CpG sites and p-values for differences between never, former, and current smokers, as determined by linear regression using M-values for methylation with adjustment for age, ethnicity, time-since-menopause, treatment, and estimated blood cell fractions, are plotted as a function of genomic location. The solid red and blue lines indicate the significant (p = 6.7 × 10–8) and suggestive (p = 6.7 × 10–6) thresholds for significance, respectively

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