An epigenome-wide association study of insulin resistance in African Americans

Clinical Epigenetics

Table 4 Relationship between DNA methylation and gene expression as reported in the IMETHYL database

CpG ID	Nearest gene^a	Gene feature^a	Methylation level^b	Methylation average^b % (SD)	FPKM^b,c average (SD)
cg14013695	HOXA5	TSS1500	High	85.3 (11.2)	− 0.11 (0.39)
cg00456326	OSR1	TSS1500	Low	35.0 (12.0)	− 0.64 (0.18)
cg20259981	ST18	5'UTR	High	94.2 (5.3)	Data not available

^aAnnotation was performed via IlluminaHumanMethylation450kanno.ilmn12.hg19. Homo sapiens (human) genome assembly GRCh37 (hg19). Hansen [20] IlluminaHumanMethylation450kanno.ilmn12.hg19: Annotation for Illumina's 450 k methylation arrays. R package version 0.6.0
^bMethylation level according to iMETHYL database (low, medium, high). IMETHYL provides whole-DNA methylation (~ 24 million autosomal CpG sites), whole-genome (~ 9 million single-nucleotide variants), and whole-transcriptome (> 14 000 genes) data for CD4⁺ T-lymphocytes, monocytes, and neutrophils collected from approximately 100 subjects. Komaki et al. [23] iMETHYL: an integrative database of human DNA methylation, gene expression, and genomic variation. Hum Genome Var 5, 18,008 (2018)
^cFPKM = Fragments Per Kilobase of transcript per Million mapped reads

ISSN: 1868-7083