An epigenome-wide association study of insulin resistance in African Americans

Clinical Epigenetics

Table 3 Top 5 differentially methylated regions associated with insulin resistance in African American men

DMR^a	Chr^b	Start^c	End^c	Gene name^c	No of CpG sites	P-value	FWER^d	Direction of effect
1	7	27,182,493	27,183,806	HOXA5	17	2.4e − 05	0.124	hypomethylated
2	17	79,905,236	79,905,263	MYADML2	3	1.9e − 04	0.553	hypomethylated
3	17	41,277,974	41,278,380	BRCA1	10	2.1e − 04	0.683	hypomethylated
4	16	53,407,013	53,407,808	CHD9	7	2.6e − 04	0.703	hypomethylated
5	22	24,384,105	24,384,400	GSTT1	10	2.7e − 04	0.766	hypomethylated

^aDMR = Differentially methylated region
^bChr = Chromosome
^cAnnotation was performed via IlluminaHumanMethylation450kanno.ilmn12.hg19. Homo sapiens (human) genome assembly GRCh37 (hg19). Hansen [20] IlluminaHumanMethylation450kanno.ilmn12.hg19: Annotation for Illumina's 450 k methylation arrays. R package version 0.6.0
^dFWER = family-wise error rate (an FWER < 0.05 is considered significant)

ISSN: 1868-7083