An epigenome-wide association study of insulin resistance in African Americans

Clinical Epigenetics

Table 2 Top 10 DMPs associated with insulin resistance in African American men

No	CpG ID	Chr	Position	Gene name^a	Feature^a	Relation to Island^a	Delta β value	P. value	FDR^f
1	cg14013695	7	27,184,176	HOXA5	TSS1500^b	Island	− 0.016	1.87e − 07	0.035
2	cg00456326	2	19,560,467	OSR1	TSS1500^b	N_Shore	0.027	2.42e − 07	0.035
3	cg20259981	8	53,301,664	ST18	5'UTR^c	OpenSea	− 0.010	2.48e − 07	0.035
4	cg14364984	14	53,310,508	Intergenic	Intergenic^d	OpenSea	− 0.014	8.68e − 07	0.093
5	cg22885024	8	95,274,933	GEM	TSS1500^b	S_Shore	− 0.005	1.28e − 06	0.107
6	cg10584797	1	26,126,588	SEPN1	TSS200^e	OpenSea	0.002	1.50e − 06	0.107
7	cg18886071	1	160,617,057	SLAMF1	5'UTR^c	OpenSea	0.023	1.87e − 06	0.115
8	cg13437337	2	220,300,109	SPEG	Body	Island	0.002	2.21e − 06	0.118
9	cg10170677	12	51,985,615	SCN8A	5'UTR^c	S_Shore	0.002	4.80e − 06	0.209
10	cg20817131	7	27,184,167	HOXA5	TSS1500^b	Island	− 0.026	5.32e − 06	0.209

^aAnnotation was performed via IlluminaHumanMethylation450kanno.ilmn12.hg19. Homo sapiens (human) genome assembly GRCh37 (hg19). Hansen [20] IlluminaHumanMethylation450kanno.ilmn12.hg19: Annotation for Illumina's 450 k methylation arrays. R package version 0.6.0
^bTSS1500—transcription start site 1500 (the region from Transcription start site (TSS) to − 1500 nucleotides upstream of TSS)
^c5’UTR—5′ untranslated region (the region of an mRNA that is directly upstream from the initiation codon)
^dCpG is located approximately 25 kilobases (kb) downstream of FERMT2 gene
^eTSS200—transcription start site 200 (the region from Transcription start site (TSS) to − 200 nucleotides upstream of TSS)
^fFDR = false discovery rate (a 5% FDR is considered significant)

ISSN: 1868-7083