Skip to main content
Fig. 3 | Clinical Epigenetics

Fig. 3

From: Shifts in the immunoepigenomic landscape of monocytes in response to a diabetes-specific social support intervention: a pilot study among Native Hawaiian adults with diabetes

Fig. 3

Changes in monocyte inflammatory response between intervention timepoints determined by monocyte intracellular cytokine staining (Mono-ICS). a Unsupervised hierarchical cluster analysis (Manhattan distance, complete linkage method) of the DML from a subset of participants subjected to Mono-ICS. b–c Figures represent the frequency of monocytes producing inflammatory cytokines at baseline (orange) and post-intervention (green) for b IL-1β, c IL-6 for two conditions: non-stimulated (No-Stim) and stimulation with inflammatory stimuli (LPS). Δ represents the difference in the frequency of cytokine-producing monocyte between LPS and No-Stim conditions. IL-1β, interleukin 1-beta; IL-6, interleukin 6; LPS, lipopolysaccharide. Bottom figures represent gating strategy employed for quantifying the frequency (%) of cytokine secreting monocytes from both treatments for b & c. P value for < 0.05, < 0.01, < 0.001, indicated by *, **, ***, respectively

Back to article page