Fig. 3
From: Therapeutic potential of inhibiting histone 3 lysine 27 demethylases: a review of the literature
KDM6B inhibition in T cell acute lymphoblastic leukaemia. T cell acute lymphoblastic leukaemia (T-ALL) involves the oncogenic transformation and expansion of T cell progenitors. T-ALL cells overexpress KDM6B, which predominantly occupies the promoter regions of oncogenic genes that are targets of NOTCH1 signalling, including HEY1, NRARP and HES1. Indeed, in T-ALL, mutations in the NOTCH1 receptor result in ligand-independent, spontaneous receptor activation and signalling. GSK-J4 suppresses the growth of T-ALL cells by increasing the levels of the repressive mark H3K27me3 without influencing KDM6B occupancy. This figure was created in BioRender.com