Skip to main content

Table 2 Relative contributions of six components to GrimAA in the CARDIA sample from QGC and BKMR

From: Relative contributions of six lifestyle- and health-related exposures to epigenetic aging: the Coronary Artery Risk Development in Young Adults (CARDIA) Study

Lifestyle components by Y20

Weights from QGC

PIPs from BKMR

Alcohol consumption

0.129

0.997

Diet quality

 − 0.537

0.310

Education years

 − 0.463

0.812

Physical activity

0.024

0.040

Sleep hours

0.010

0.091

Smoking

0.835

1.000

Collective association†

5.15 (95% CI 4.16, 5.86), p < 0.001

3.62 (95% CrI 1.93, 5.22)

  1. Models were adjusted for race, sex, body mass index (BMI), and field center; CI confidence interval, CrI credible interval, QGC quantile-based g-computation, BKMR Bayesian kernel machine regression, PIPs posterior inclusion probabilities. The positive and negative weights from QGC represents the proportion of the effect estimate for each component (sum up to 1 or − 1 for the same direction); The PIP reflects the ranked importance of each component in association with GrimAA. † Change in mean GrimAA per one quartile change of all six components for QGC; change in mean GrimAA when all of the six lifestyle components are fixed at their 75th percentile compared to when the six lifestyle components are at their 25th percentile for BKMR