Skip to main content
Fig. 4 | Clinical Epigenetics

Fig. 4

From: Noninvasive early detection of colorectal cancer by hypermethylation of the LINC00473 promoter in plasma cell-free DNA

Fig. 4

Methylation of LINC00473 in cfDNA from patients with advanced colorectal polyps and colorectal cancer. A Methylation status of LINC00473 promoter in plasma cfDNA of CRC patients analyzed by qMSP (Cohort 5). B ROC curve analysis evaluating the methylation of LINC00473 for the detection of CRC in plasma cfDNA (Cohort 5). C, Methylation status of LINC00473 promoter in plasma cfDNA of patients with ACP analyzed by qMSP (Cohort 6). D ROC curve analysis evaluating the methylation of LINC00473 for the detection of ACP in plasma cfDNA (Cohort 6). E Validation of the methylation status of LINC00473 promoter in plasma cfDNA of patients with ACP by ddPCR analysis (Cohort 7). F, ROC curve analysis to validate the methylation of LINC00473 for the detection of ACP and CRC in plasma cfDNA (Cohort 7). Horizontal lines represent mean methylation levels of LINC00473. P, p value analyzed by Mann–Whitney U test or ROC curve; AUC, area under the ROC curve; Ctrl, controls. ACP, advanced colorectal polyps; CRC, colorectal cancer.

Back to article page