Skip to main content
Fig. 3 | Clinical Epigenetics

Fig. 3

From: Noninvasive early detection of colorectal cancer by hypermethylation of the LINC00473 promoter in plasma cell-free DNA

Fig. 3

Methylation levels of LINC00473 in tissue precancerous colorectal lesions. A Methylation levels of LINC00473 promoter in tissues from premalignant colorectal polyps, CRC and matched normal colorectal mucosa (controls) by pyrosequencing (Cohort 3). B, C Methylation levels of LINC00473 promoter in tissues from N-ACP, ACP and CRC (Cohort 3) analyzed by pyrosequencing. D ROC curve analysis evaluating the methylation of LINC00473 promoter for the detection of ACPs with respect to the combination of controls and N-ACPs (Cohort 3). E ROC curve to evaluate the methylation of LINC00473 promoter for the detection of AN with respect to the combination of controls and N-ACPs (Cohort 3). Horizontal lines represent mean methylation levels of LINC00473. P, p value analyzed by Mann–Whitney U test or ROC curve; AUC, area under the ROC curve; Ctrl, controls; P, polyps; CRC, colorectal cancer; N-ACP, non-advanced colorectal polyps; ACP, advanced colorectal polyps; AN, advanced neoplasia

Back to article page

Clinical Epigenetics

ISSN: 1868-7083

Contact us